• Case Studies in Veterinary Immunology presents basic immunological concepts in the context of actual cases seen in clinics. It is intended for veterinary medicine students, interns, residents, and veterinarians, and serves as a valuable supplement and companion to a variety of core immunology textbooks and courses.

    The book includes cases describing primary immune system defects, secondary immune system defects, and hypersensitivity and autoimmune disorders, as well as dysproteinemias and lymphoid neoplasia. Drawing on the successful approach of Geha’s Case Studies in Immunology, each representative case is preceded by a discussion of the principles underlying that specific immunological mechanism. The case itself includes the presenting complaint (signalment), physical examination findings, pertinent diagnostic laboratory data, diagnosis, and treatment options. In those instances in which a specific disorder occurs in both animals and humans, the differences and similarities in the immunological mechanisms and manifestations of the disease are explored. End of case questions highlight important concepts and serve as a review aid for students. Details on standard vaccines and vaccination schedules, as well as descriptions of the types of assays used for evaluation of the immune system, are included as appendices.

  • 1. Primary Ciliary Dyskinesia—Canine
    2. Leukocyte Adhesion Deficiency—Bovine
    3. Cyclic Neutropenia—Canine
    4. Chediak–Higashi Syndrome—Feline
    5. Severe Combined Immunodeficiency—Equine
    6. Selective IgA Deficiency—Canine
    7. Failure of Passive Transfer—Equine
    8. Feline Leukemia Virus—Feline
    9. Feline Immunodeficiency Virus—Feline
    10. Bovine Virus Diarrhea Virus—Bovine
    11. Marek’s Disease—Avian
    12. Infectious Bursal Disease—Avian
    13. Bovine Respiratory Disease Complex—Bovine
    14. Allergic Asthma—Feline
    15: Atopic Dermatitis—Canine
    16. Culicoides Hypersensitivity—Equine
    17. Systemic Anaphylaxis—Equine
    18. Neonatal Isoerythrolysis—Equine
    19. Immune Mediated Hemolytic Anemia—Canine
    20. Evan’s Syndrome—Equine
    21. Pemphigus Foliaceus—Canine
    22. Acquired Myasthenia Gravis—Canine
    23. Systemic Lupus Erythematosus—Canine
    24. Purpura Hemorrhagica—Equine
    25. Contact Dermatitis—Canine
    26. Autoimmune Thyroiditis—Canine
    27. Recurrent Airway Obstruction—Equine
    28. Flea Allergy Dermatitis—Canine
    29. Multiple Myeloma—Canine
    30. Feline Infectious Peritonitis—Feline
    31. Monocytic Ehrlichiosis—Canine
    Appendix I: Vaccines and Vaccination Schedules
    Appendix II: The Clinical Immunology Laboratory

  • Laurel Gershwin

    Professor and Agronomist

    Pathology, Microbiology & Immunology

    Diplomate American College of Veterinary Microbiologists, Bacteriology, Mycology, Virology, & Immunoogy

    State Licensure for practice of veterinary medicine - California

    State Licensure for practice of veterinary medicine- Massachusetts

    State Licensure for practice of veterinary medicine - Maryland


    1969, BS, University of California, Davis, Davis, CA

    1971, DVM, University of California, Davis, Davis, CA

    1979, PhD, University of California, Davis, Davis, CA

    Active Research Grants

    Principal Investigator, Augmentation of antiviral immunity by nasal inoculation of bovine upper respiratory epithelium with noncytotoxic Histophilus somni, (Principal Investigator), USDA NRI

    Principal Investigator, Combined Immunomodulation and Anti-viral Therapy for Respiratory Syncytial Virus, (Principal Investigator), USDA AFRI - funding from the Dual Purpose/Dual Benefit RFA with NIH

    Most Recent Five Book Chapters

    2014 Gershwin LJ: Exposure to Allergens During Development, R Halding, K Pinkerton, S Hopper, C Plopper, (ed), The Lung: Development, Aging, and the Environment, second edition, . .

    2013 Gershwin LJ: Chapter 2: Immune Responses to Infectious Agents, Hirsh DC, MacLachlan NJ, Walker RL, (ed), Veterinary Microbiology, third edition, Malden, MA. .

    2008 Plopper CG, Smiley-Jewell SM, Miller LA, Fanucchi MV, Evans MJ, Buckpitt AR, Avdalovic M, Gershwin LJ, Joad JP, Kajekar R, Larson S, Pinkerton KE, Van Winkle LS, Schelegle ES, Pieczarka EM, Wu R, Hyde DM: Primate Models of Allergic Asthma, Kay BA, (ed), Allergy and Allergic Disease, Second Edition, London. Chapter 54.

    2008 Gershwin LJ: Clinical Veterinary Immunology, 6th edition, Kaneko JJ, Harvey JW, Bruss ML, (ed), Clinical Biochemistry of Domestic Animals, . 157-172.

    2004 Gershwin LJ: Exposure to Allergens During Development, Halding R, Pinketon K, Hopper S, Plopper C, (ed), In: The Lung: Development, Aging, and the Environment, Ch 22, . 311-319.

    Research Focus

    IgE/allergic responses, bovine respiratory syncytial virus (BRSV) pathogenesis and effects of air pollutants (environmental tobacco smoke and ozone) on pulmonary allergic disease/asthma

    Specialty Focus