• Pathology of Laboratory Swine is a comprehensive text describing the spontaneous pathology seen in common laboratory pig strains. As the first book collating information on all organ systems in these strains, this resource will serve as a “go to” text for all pathologists working on laboratory pigs in safety assessment studies and for veterinary pathologists who need a diagnostic tool to rule out spontaneous, non-clinical disease pathology when assigning cause of death to these animals which are also kept as domestic pets.

    Key features

    • Consists of multi-author chapters arranged by organ systems
    • Provides color illustrations that depict the most common lesions to augment descriptions
    • Presents pathologists with common terms that are compliant with the FDA’s Standard for Exchange of Nonclinical Data (SEND) guidelines
    • Gives references for recommended tissue trimming planes

  • 1. Choice of Pig model

    2. Regulatory issues in the use of minipigs

    3. Infectious Diseases

    4. Clinical Examination

    5. Digestive System (Oral Cavity, Salivary glands, Esophagus and Stomach, Small and Large Intestine

    6. Liver

    7. Exocrine Pancreas

    8. Urinary System (Kidney, Urinary bladder, ureter, urethra

    9. Nervous System

    10. Eye and associated glands

    11. Skeletal Muscle

    12. Bone and Joints

    13. Skin and subcutis (including specialized sebaceous glands)

    14. Mammary Gland

    15. Respiratory trac
    t16. Haemopoietic and Lymphoid System

    17. Female Reproductive Tract

    18. Male Reproductive Tract

    19. Cardiovascular System

    20. Endocrine System (Thyroid, Parathyroid, Pituitary, Adrenal and Endocrine Pancreas

    21. Clinical Pathology (Hematology and Clinical Chemistry)

    22. Juvenile

    23. Immunohistochemistry

  • Kristi Helke

    Received her DVM in 2000 from the University of Wisconsin- Madison and completed a Fellowship from 2001-2005 in Veterinary Comparative Pathology at the Johns Hopkins University School of Medicine. She also obtained a Ph.D. in 2007 from Johns Hopkins University School of Medicine. Her pathology residency was also completed at Johns Hopkins University, and she is a diplomate of the American College of Veterinary Pathologists. Dr. Helke is currently a professor and Chair of the Department of Comparative Medicine at the Medical University of South Carolina. While there, she has completed several studies for biomedical companies in which she evaluated mice, rats, dogs and pigs for toxicologic changes to novel therapeutics and adverse reactions to both biomedical materials and devices. She also works closely with researchers to develop animal models and pathologic analysis of these models.

    Affiliations and expertise

    Professor and Chair, Department of Comparative Medicine, Medical University of South Carolina, USA

    Keith Nelson

    Has over 15 years experience in toxicologic pathology, working for multiple contract research organizations. He completed his undergraduate and DVM degrees at Michigan State University before spending a year at Oregon State University studying fish immunology and a year in Kenya studying hyena behavior. He then completed his residency and PhD training at Colorado State University, after which he joined MPI Research, intending to “try out” toxicologic pathology. Almost two decades later, he remains excited about the field and has served as a pathologist, leader and mentor at large CROs, and adjunct assistant professor at Michigan State University. He is active within the field of anatomic and toxicologic pathology, holding multiple committee leadership positions in STP and ACVP, serving on the INHAND Minipig committee for harmonization of nomenclature, and publishing and presenting on a wide range of pathology topics.

    Affiliations and expertise

    Director, Toxicologic Pathology, Inotiv, Portage, MI, USA

    Aaron M. Sargeant

    Is a Scientific Director, Pathology at Charles River Laboratories in Spencerville, OH, USA.

    Affiliations and expertise

    Scientific Director, Pathology, Charles River Laboratories, Spencerville, OH, USA

    Alys Bradley

    Has been with Charles River since 1998 where she is the senior director of pathology. In this capacity she leads a team of veterinary pathologists and pathology analysts. She has specialist interest and provides consultancy services in neuropathology, non-human primate pathology, medical devices, and cellular therapy products (human and animal stem cells). She is an experienced study pathologist for acute, long term reproductive toxicology, tumorigenicity, oncogenicity, microautoradiography, target animal safety and carcinogenicity studies. She has authored over 700 GLP or GMP compliant toxicological peer reviewed pathology and photomicroscopy reports. She is the GLP and GMP Study Director as well as the Quality Control Manager for GMP pathology services.

Veterinary Clinics of North America
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