Medicina Laboratorial e Patologia Clínica
Pathology of Genetically Engineered and Other Mutant Mice
De: John P. Sundberg (Editor), Jerrold M. Ward (Editor), Peter Vogel (Editor)
ISBN: 9781119624578
2021, Wiley
Capa dura
Páginas: 496
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Pathology of Genetically Engineered and Other Mutant Mice delivers a comprehensive resource for pathologists and biomedical scientists tasked with identifying and understanding pathologic changes in genetically modified mice. The book is organized by body system, includes descriptions and explanations of a wide range of findings, as well as hundreds of color photographs illustrating both common and rare lesions that may be found in genetically engineered and wild type mice.
The book is written by experienced veterinary and medical pathologists working in veterinary medical colleges, medical colleges, and research institutes. Covering the latest discoveries in mouse pathology resulting from advancements in biotechnology research over the last 30 years, this singular and accessible resource is a must-read for veterinary and medical pathologists and researchers working with genetically engineered and other mice.
Readers will also benefit from:
- A thorough introduction to mouse pathology and mouse genetic nomenclature, as well as databases useful for analysis of mutant mice
- An exploration of concepts related to validating animal models, including the Cinderella Effect
- Practical discussions of basic necropsy methods and grading lesions for computational analyses
- Concise diagnostic approaches to the respiratory tract, the oral cavity and GI tract, the cardiovascular system, the liver and pancreas, the skeletal system, and other tissues
As a one-stop and up to date reference on mouse pathology, Pathology of Genetically Engineered and Other Mutant Mice is an essential book for veterinary and medical pathologists, as well as for scientists, researchers, and toxicologists whose work brings them into contact with genetically modified mice.
Contributors List
Preface and Acknowledgements
Chapter 1. Introduction to Mouse Pathology
Jerrold M. Ward, Peter Vogel, John P. SundbergChapter 2. The Mouse Online: Open Mouse Biology and Pathology Data Resources for Biomedical Research
Dale A. Begley, Paul N. Schofield, and John P. SundbergChapter 3. Mouse Genetic Nomenclature; the Underpinning of Mouse Genetics
John P. Sundberg, Dale Begley, Melissa Berry, Michelle N. Perry, David Shaw, and Paul N. SchofieldChapter 4. Discovering and Validating Mouse Models of Human Diseases: The Cinderella Effect
John P. Sundberg, Jerrold M. Ward, Peter Vogel, and Paul N. SchofielChapter 5. Embryos, Placentas, and Neonates
Brad Bolon and Jerrold M. WardChapter 6. Ciliopathies
Peter Vogel and Laura L. JankeChapter 7. Hematopoietic and Lymphoid Tissues
Harm HogenEsch and John P. SundbergChapter 8. Hematolymphoid Neoplasms
Jerold E. RehgChapter 9. Immunodeficient and Humanized Mice
Sara F. Santagostino, Sébastien Monette, Alessandra Piersigilli, Virginia L. Godfrey, and Harm HogenEschChapter 10. Skin, Hair, and Nails
John P. Sundberg, Lloyd E. King, Jr., Raoul V. KuiperChapter 11. Mammary Gland
Alexander D. Borowsky and Robert D. CardiffChapter 12. Respiratory System
Jerry M. Ward and John P. SundbergChapter 13. Gastrointestinal Tract
Jerrold M. Ward, Piper M. Treuting, M. Kay WashingtonChapter 14. Cardiovascular System
Kathleen Gabrielson, Akash Behera, Polina Sysa-Shah, Tyler J. Creamer, and Timothy CooperChapter 15. Liver and Pancreas
Maria L.Z. Dagli, Lucas M. Chaible, and Katja SteigerChapter 16. Neuromuscular System
Peter Vogel, Laura L. Janke, and Heather S. TillmanChapter 17. Endocrine System
Krista Marie DuBray La PerleChapter 18. Kidney and Urinary Bladder
Jeffrey B. Kopp, Cory F. Brayton, Jeffrey Everett, Avi Z. Rosenberg, Jerrold M. WardChapter 19. Female Reproductive Tract
Darlene Dixon and Alexander NikitinChapter 20. Male Reproductive Tract
Sue E. Knoblaugh, Hibret A. Adissu, Colin McKerlie, Robert D. CardiffChapter 21. Nervous System
Jessica M. Snyder, Katherine N. Gibson-Corley, and Enrico RadaelliChapter 22. Eye and Ear
Heather Tillman, Laura Janke, Jerold Rehg, Peter VogelChapter 23. Bones and teeth
Peter Vogel, John P. Sundberg, Cheryl Ackert-BicknellIndex
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John P. Sundberg, DVM, PhD, DACVP, is Professor at The Jackson Laboratory in Bar Harbor, Maine, USA and an Adjunct Professor in the Department of Dermatology, Vanderbilt University Medical Center in Nashville, TN, USA.
Jerrold M. Ward, DVM, PhD, DACVP, FIATP,is an Adjunct Faculty member at The Jackson Laboratory, Bar Harbor, Maine, USA and Adjunct Professor in the Department of Biomedical Sciences at Cornell University College of Veterinary Medicine in Ithaca, New York, USA.
Peter Vogel, DVM, PhD,DACVP, is Director of the Veterinary Pathology Core Laboratory at St. Jude Children’s Research Hospital in Memphis, Tennessee, USA.