• Use the veterinarian’s #1 reference on general pathology and the pathology of organ systems! Pathologic Basis of Veterinary Disease, 7th Edition helps you understand and diagnose diseases of domestic animals by using the latest scientific and medical research. Focusing on dogs, cats horses, cattle, sheep, goats, and pigs, this reference describes and vividly illustrates and explores the pathogeneses of animal diseases, how cells and tissues respond to injury, and the morphology (lesions) of this injury. New to this edition is basic coverage of tumor, inflammatory, and microbial cytology. Edited by veterinary pathologist James F. Zachary and a team of expert veterinary pathologists, this book includes access to an enhanced eBook with every new print purchase, featuring a fully searchable version of the entire text, an image collection, and much more – and available on a variety of devices.

    New to this edition

    • NEW! Coverage of the cytomorphology and histomorphology of tumors, inflammatory cells and exudates, and microbes commonly seen in the practice of veterinary medicine.
    • NEW! Coverage of a procedure used to collect specimens for cytologic evaluation.
    • NEW! Pathogenesis Pathways flowcharts designed to arrange each step of a disorder in chronologic, mechanistic order.

    Key Features

    • Clear, up-to-date illustrations and explanations of the macroscopic (gross) and microscopic lesions resulting from diseases occurring in domestic animals
    • Complete coverage of both general pathology and the pathology of organ systems that includes the latest research, practice, and diagnostic information on disease mechanisms, pathogenesis, and lesions.
    • Clear explanations of disease mechanisms that describe cell, tissue, and organ system responses to injury and infection.
    • Easy-to-follow organization for each systemic disease chapter including a brief review of the study of diseases that occur in specific tissues, organs, and organ systems, with basic principles related to anatomy, structure, and function, followed by congenital and functional abnormalities and discussions of infectious disease responses, helping students apply principles to veterinary practice.
    • More than 2,100 full-color illustrations featuring color photographs, schematics, flow charts, and diagrammatic representations of disease processes as well as summary tables and boxes, making it easier to understand difficult concepts.
    • Content on cellular and organ system pathology updated throughout the book, with expanded coverage of genetics and disease.
    • Key Readings Index in each chapter with page numbers for key topics.
    • Essential Concept boxes in each General Pathology chapter break down complicated topics that are critical to understanding lesions and pathogeneses.
    • More than 20 recognized experts deliver the most relevant information for the practitioner, student, or individual preparing for the American College of Veterinary Pathologists’ board examination.
    • An enhanced eBook is included with new print purchase, featuring the complete, fully searchable text plus an image collection; the text, tables, and boxes linked to the website that are cited throughout the book; ten new appendices that focus on veterinary diagnostic pathology, postmortem examination, interpretation of lesions, and more; plus an established appendix of photographic techniques used in veterinary diagnostic pathology.

  • Cover image
    Title page
    Copyright
    Contributors
    Preface
    Introduction. Fundamentals for Understanding Veterinary Pathology
    Information Fundamental for Effective Use of this Book
    In Conclusion
    Section I. Cellular and Molecular Mechanisms of Disease
    (General Pathology)
    Introduction

    Chapter 1. Mechanisms and Morphology of Cellular Injury, Adaptation, and Death

    Introduction
    Normal Cell
    Causes of Cell Injury
    Irreversible Cell Injury and Cell Death
    Chronic Cell Injury and Cell Adaptations
    Cell Cycle
    Cellular Aging
    Genetic Basis of Disease

    Chapter 2. Vascular Disorders and Thrombosis
    Introduction
    Circulatory System
    Microcirculation, Interstitium, and Cells
    Fluid Distribution and Homeostasis
    Abnormal Fluid Distribution
    Hemostasis
    Disorders of Hemostasis: Hemorrhage and Thrombosis
    Normal Blood Flow, Distribution, and Perfusion
    Alterations in Blood Flow and Perfusion
    Shock

    Chapter 3. Inflammation and Healing
    Introduction
    Evolution of the Current Understanding of Inflammation
    Beneficial and Harmful Aspects of Inflammation
    Acute Inflammation
    Substances Inducing the Acute Inflammatory Response
    Fluidic (Exudative) Phase of the Acute Inflammatory Response
    Cellular Phase of the Acute Inflammatory Response
    Additional Regulation of Inflammation
    Inflammation and Pain
    Effector Cells of the Acute Inflammatory Response
    Chemical Mediators of the Acute Inflammatory Response
    Reparative Phase of the Acute Inflammatory Response
    Nomenclature of the Inflammatory Response (Morphologic
    Diagnoses)
    Morphologic Classification of Exudates in Acute Inflammatory
    Lesions
    Chronic Inflammation
    Beneficial and Harmful Aspects of Chronic Inflammation
    Progression of the Acute Inflammatory Response to Chronic
    Inflammation, Fibrosis, and Abscess Formation
    Gross and Microscopic Lesions and Nomenclature of the
    Chronic Inflammatory Response
    Effector Cells and Cellular Mechanisms of Chronic Inflammatory
    Responses
    Inflammation and the Sensation of Pain
    The Effect of Inflammation on the Febrile Response and Other
    Activities
    Unique Types of Inflammation
    Cytologic and Histologic Comparisons of Inflammatory Exudates
    Wound Healing and Angiogenesis

    Chapter 4. Mechanisms of Microbial Infections
    Introduction
    Chronologic Sequence of Steps in Microbial Diseases
    Portals of Entry
    Target Cells and Substances
    Pathways of Spread
    Defense Mechanisms
    Genetic Resistance of Animals to Infectious Diseases
    Bacterial Diseases
    Viral Diseases
    Fungal Diseases (Mycoses)
    Protozoan Diseases
    Prion Diseases (Spongiform Encephalopathies)

    Chapter 5. Diseases of Immunity
    General Features of the Immune System
    Innate Immunity (Nonspecific Immunity)
    Adaptive Immunity (Specific Immunity)
    Disorders of the Immune System

    Chapter 6. Neoplasia and Tumor Biology
    Introduction
    General Nomenclature
    Tumor Characteristics (Essential Concept 6.1)
    Neoplastic Transformation (Essential Concept 6.2)
    Tumor Microenvironment (Essential Concept 6.3)
    Tumor Immunity (see Essential Concept 6.3)
    Tumor Dissemination (Essential Concept 6.4)
    Systemic Clinical Effects on the Animal (see Essential Concept
    6.3)
    Heritable Alterations in Cancer (Essential Concept 6.5)
    Molecular Determinants of Cancer
    Mechanisms of Carcinogenesis
    Cancer in Animals

    Section II. Pathology of Organ Systems
    Introduction

    Chapter 7. Alimentary System and the Peritoneum, Omentum, Mesentery, and Peritoneal Cavity
    Introduction
    Structure and Function
    Dysfunction/Responses to Injury
    Portals of Entry/Pathways of Spread
    Defense Mechanisms/Barrier Systems
    Diseases Affecting Multiple Species of Domestic Animalsc,d
    Diseases of Horses
    Diseases of Ruminants (Cattle, Sheep, and Goats)
    Diseases of Pigs
    Diseases of Dogs
    Diseases of Cats

    Chapter 8. Hepatobiliary System and Exocrine Pancreas Liver and Intrahepatic Biliary System
    Gallbladder and Extrahepatic Bile Ducts
    Exocrine Pancreas

    Chapter 9. Respiratory System, Thoracic Cavities, Mediastinum, and Pleurae
    Introduction
    Structure and Function
    Dysfunction/Responses to Injury
    Portals of Entry/Pathways of Spread
    Defense Mechanisms/Barrier Systems
    Diseases Affecting Multiple Species of Domestic Animals
    Diseases of Horses
    Diseases of Ruminants (Cattle, Sheep, and Goats)
    Diseases of Pigs
    Diseases of Dogs
    Diseases of Cats

    Chapter 10. Cardiovascular System, Pericardial Cavity, and Lymphatic Vessels
    Structure
    Function
    Dysfunction/Responses to Injury
    Portals of Entry/Pathways of Spread
    Defense Mechanisms/Barrier Systems
    Diseases Affecting Multiple Species of Domestic Animals
    Diseases of Horses
    Diseases of Ruminants (Cattle, Sheep, and Goats)
    Diseases of Pigs
    Diseases of Dogs
    Diseases of Cats

    Chapter 11. The Urinary System
    Kidney
    Lower Urinary Tract

    Chapter 12. Endocrine System
    Structure and Function
    Dysfunction/Responses to Injury
    Portals of Entry/Pathways of Spread
    Defense Mechanisms/Barrier Systems
    Diseases Affecting Multiple Species of Domestic Animals
    Diseases of Horses
    Diseases of Ruminants (Cattle, Sheep, and Goats)
    Diseases of Pigs
    Diseases of Dogs
    Diseases of Cats
    Chapter13. Bone Marrow, Blood Cells, and the Lymphoid/Lymphatic
    System
    Introduction
    Bone Marrow and Blood Cells

    Chapter 14. Nervous System
    The Nervous System
    Central Nervous System
    Peripheral Nervous System

    Chapter 15. Skeletal Muscle
    Structure
    Function
    Dysfunction/Responses to Injury
    Portals of Entry/Pathways of Spread
    Defense Mechanisms/Barrier Systems
    Diseases Affecting Multiple Species of Domestic Animals
    Diseases of Horses
    Diseases of Ruminants (Cattle, Sheep, and Goats)
    Diseases of Pigs
    Diseases of Dogs
    Diseases of Cats
    Chapter 16. Bones, Joints, Tendons, and Ligaments
    Introduction
    Structure and Function
    Dysfunction/Responses to Injury
    Portals of Entry/Pathways of Spread
    Defense Mechanisms/Barrier Systems
    Diseases Affecting Multiple Species of Domestic Animals
    Diseases of Horses
    Diseases of Ruminants (Cattle, Sheep, and Goats)
    Diseases of Pigs
    Diseases of Dogs
    Diseases of Cats

    Chapter17. The Integument
    Structure
    Function
    Dysfunction/Responses to Injury
    Portals of Entry/Pathways of Spread
    Defense Mechanisms/Barrier Systems
    E-Appendix 17.1. Postmortem Evaluation of the Skin, Claws,
    Pawpads, and Hooves
    Diseases Affecting Multiple Species of Domestic Animals
    Diseases of Horses
    Diseases of Ruminants (Cattle, Sheep, and Goats)
    Diseases of Pigs
    Diseases of Dogs
    Diseases of Cats

    Chapter 18. Female Reproductive System and Mammae
    Introduction
    E-Appendix 18.1 Techniques Used to Examine the Female
    Reproductive System and Mammae
    Structure
    Function
    Dysfunction/Responses to Injury
    Portals of Entry/Pathways of Spread
    Defense Mechanisms/Barrier Systems
    Diseases Affecting Multiple Species of Domestic Animals
    Diseases of Horses
    Diseases of Ruminants (Cattle, Sheep, and Goats)
    Diseases of Pigs
    Diseases of Dogs
    Diseases of Cats

    Chapter 19. Male Reproductive System
    E-Appendix 19.1 Methods for Examining the Male Reproductive
    Tract
    Introduction
    Structure
    Function
    Dysfunction/Responses to Injury
    Portals of Entry/Pathways of Spread
    Defense Mechanisms/Barrier Systems
    Diseases Affecting Multiple Species of Domestic Animals
    Diseases of Horses
    Diseases of Ruminants (Cattle, Sheep, and Goats)
    Diseases of Pigs
    Diseases of Dogs
    Diseases of Cats

    Chapter 20. The Ear
    Introduction
    Structure and Function
    E-Appendix 20.1. Histologic Evaluation of the Internal Ear
    Dysfunction/Responses to Injury
    Portals of Entry/Pathways of Spread
    Defense Mechanisms/Barrier Systems
    Diseases Affecting Multiple Species of Domestic Animals
    Diseases of Horses
    Diseases of Ruminants (Cattle, Sheep, and Goats)
    Diseases of Pigs
    Diseases of Dogs
    Diseases of Cats

    Chapter 21. The Eye
    Introduction
    Structure and Function
    Dysfunction/Response to Injury
    Portals of Entry/Pathways of Spread
    Defense Mechanisms/Barrier Systems
    E-Appendix 21.1 Postmortem Technique
    Diseases Affecting Multiple Species of Domestic Animals
    Diseases of Horses
    Diseases of Ruminants (Cattle, Sheep, and Goats)
    Diseases of Pigs
    Diseases of Dogs
    Diseases of Cats

    Section III: Appendices, Veterinary Diagnostic Pathology
    Introduction
    Appendix A. Communication, Collaboration, and Consultation in
    Veterinary Pathology
    Appendix B. Photographic Techniques in Veterinary Pathology
    Appendix C. Postmortem Examination (Autopsy) of Domestic Animal
    Species
    Appendix D. Recognition and Interpretation of Macroscopic (Gross)
    Lesions
    Appendix E. Diagnoses in Veterinary Pathology
    Appendix F. General Principles of Tissue Fixation and Processing
    Appendix G. Fixatives and Fixation
    Appendix H. Fixation and Trimming of the Brain, Spinal Cord, and Nerves
    Appendix I. Surgical Biopsies—Procurement, Processing, and Sectioning
    Artifacts
    Appendix J. Gross Examination and Infusion Fixation of the Lung
    Appendix K. Necropsy Techniques by Organ System
    Index.

  • James F. Zachary, DVM, PhD, Diplomate, American Colllege of Veterinary Pathologists; Professor of Veterinary Pathology, Department of Pathobiology, College of Veterinary Medicine, University of Illinois, Urbana, IL

Veterinary Clinics of North America
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