Introduction to Veterinary Genetics, 4th Edition
De: Frank W. Nicholas
ISBN: 9781394331505
2027, Wiley
Capa mole
Páginas: 336
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The essential textbook on genetics and genomics for veterinary and animal science
Introduction to Veterinary Genetics, now in its fourth edition, provides students and practitioners with a solid grounding in genetics and genomics in the context of veterinary medicine and animal production.
This edition incorporates revisions throughout, including advances in molecular technology and updated approaches to the diagnosis and control of inherited disease. Coverage spans basic genetics and genomics, population and quantitative genetics and genomics. A new chapter covers cancer genetics and genomics.
Readers will also find:
- Updated material on molecular technology advances reflecting current methods used in veterinary genetic diagnostics and research
- Coverage linking genetics and genomics concepts directly to animal production systems
- Discussion of parasites and pathogens from a genetic perspective, connecting host genetics to disease susceptibility and resistance
- End-of-chapter summaries in every chapter designed to support structured revision and efficient exam preparation
- Consistent terminology and coherent progression across all topics in the text
Introduction to Veterinary Genetics serves veterinary students, animal science students, and practicing veterinarians who need a reliable reference on genetic and genomic principles. Whether used as a course textbook aligned with veterinary medicine curricula or as a practitioner's desk reference, this Fourth Edition provides the updated, authoritative coverage required for informed clinical and breeding decisions.
Preface
Acknowledgements
1 Basic genetics
Chromosomes
Meiosis and mitosis
The biochemistry of inheritance
What is a gene?
Gene regulation
Mutation
Simple or Mendelian inheritance
Linkage
Inactivation
Types of DNA
Summary
Websites
Further reading
Appendix 1.1 Banded karyotypes of domestic species
2 Molecular biology
Restriction enzymes
DNA cloning and Recombinant DNA
DNA sequencing
Complementary DNA
RNA sequencing
Polymerase chain reaction (PCR)
Microsatellites
Single nucleotide polymorphisms (SNPs)
Gene mapping
Reference genome assemblies
Whole-genome sequencing (WGS)
Whole-exome sequencing (WES)
Beyond SNP chips
Comparative genomics
Production of polypeptide from cloned DNA
Transgenesis
Antisense technology
CRISPR-Cas
Summary
Websites
Further reading
3 Single-gene disorders
Inborn errors of metabolism
Sex-limited inheritance
Genetic heterogeneity of disease
Type of gene action and type of disease
Phenocopies
Congenital and non-congenital disorders
A sample of single-gene disorders
A revolution in identifying the likely causal
variant of single-gene disorders
Summary
Websites
Further reading
Appendix 3.1 Online Mendelian Inheritance in Animals (OMIA): a compendium of single-gene traits and their likely causal variants
4 Chromosomal aberrations
Abnormal chromosome number
Abnormal chromosome structure
Chromosomal aberrations in cancer
Evolution of karyotypes
Interspecific hybridization
Freemartins
Biological basis of sex
Classification of intersex
A sample of chromosomal aberrations
Summary
Further reading
Appendix 4.1 A sample of chromosomal aberrations in animals
5 Single genes in populations
Allele and genotype frequencies
Random mating
The Hardy–Weinberg law
Extensions to the Hardy–Weinberg law
Selection and mutation
Genetic drift and the founder effect
Extending population genetics to more than one locus
Summary
Websites
Further reading
6 Familial disorders not due to a single gene
Liability and threshold
The multifactorial model
More than one threshold
Heritability
Penetrance and expressivity
Future resolution of multiple factors
Recurrence risks
Summary
Further reading
7 Is it inherited?
General evidence for a genetic aetiology
The four types of simple, Mendelian inheritance
Studying and analysing the data
Summary
Websites
Further reading
8 Immunogenetics
Antibodies
Red-cell antigens
The major histocompatibility complex (MHC)
Summary
Websites
Further reading
9 Pharmacogenetics and Pharmacogenomics
Genetic polymorphisms affecting drug reaction
Genetics and anaesthesia
Warfarin resistance
Multifactorial pharmacogenetics
Summary
Websites
Further reading
10 Hosts, parasites, and pathogens
Host–pathogen interactions
Resistance in hosts
Resistance in parasites and pathogens
Control of parasites and pathogens
Increasing the level of resistance in hosts
Increasing the level of resilience in hosts
Summary
Websites
Further reading
11 Single genes in animal breeding
Coat colour
Carpet wool
Prolificacy in sheep
Polledness
Muscular hypertrophy in cattle and sheep
Dwarf poultry
Genes for sexing chickens
Parentage testing
Summary
Websites
Further reading
12 Relationship and inbreeding
The inbreeding coefficient
Relationship
Genomic relationship
The inbreeding coefficient revisited
General expressions for relationship and inbreeding
The base population
Inbreeding in populations
Runs of homozygosity
Inbreeding depression
Summary
Websites
Further reading
13 Quantitative variation
Quantitative traits
The performance of an individual animal
The differences between animals
Heritability
Correlations between traits
Quantitative trait loci (QTL)
Summary
Websites
Further reading
14 Selection between populations
Comparison between populations
Genotype–environment interaction
Comparing breeds of companion animals
Further reading
15 Selection within populations
Estimated breeding values and accuracy of selection
Phenotypic clues to a candidate’s breeding value for a trait
Combining clues from more than one source
Best linear unbiased prediction (BLUP)
Correlated traits
Selection for more than one trait
The importance of inbreeding and genetic drift
Genomic selection
Polygenic Risk Scores: genomic clues to a candidate’s phenotypic value
Ultimate genotypes
Summary
Websites
Further reading
16 Breed structure
The traditional pyramid
Closed-nucleus breeding schemes
Open-nucleus breeding schemes
Community-based breeding programmes
Summary
Websites
Further reading
17 Crossing
Regular crossing
Crossing to produce a synthetic
Designer dogs
Grading-up
Summary
Websites
Further reading
18 Selection and regular crossing
Selection
Selection and regular crossing
Summary
Further reading
19 Biotechnology
Artificial insemination (AI)
Multiple ovulation and embryo transfer (MOET)
In vitro maturation (IVM) and in vitro fertilization
(IVF) of ova
Control of sex ratio
Recombinant proteins
Transgenesis
Uses of CRISPR-Cas
Animal cloning
Animal forensics
Barcode of life
Summary
Websites
Further reading
20 Conservation genetics
Measurement of genetic diversity within populations
Measurement of genetic diversity among populations
Importance of genetic diversity
Loss of genetic diversity
Conservation of genetic diversity
Targeted genetic intervention
Summary
Websites
Further reading
21 Genetic and environmental control of inherited disorders
Environmental control of inherited disorders
Genetic control of single-gene disorders
Genetic control of multifactorial disorders
Genetic control – some final points
Crossing: thinking outside the square
Summary
Websites
Further reading
22 Cancer genetics and genomics
Mutational basis of cancer
Genome screens of cancers
Genetic variation in susceptibility to cancer
Summary
Websites
Further reading
Index
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Frank W. Nicholas
Is Emeritus Professor of Animal Genetics in the Sydney School of Veterinary Science at the University of Sydney, NSW, Australia. He is an Honorary Member of the International Society for Animal Genetics. In 2022 he was awarded Doctor Medicinae Veterinariae Honoris Causa from the University of Bern and was appointed Member (AM) of the Order of Australia. His work includes co-authoring Charles Darwin in Australia and creating the global reference website for inherited diseases in animals: Online Mendelian Inheritance in Animals (OMIA; omia.org).