• Discusses current topics in HBO, from basic research to clinical trials
    • Describes molecular mechanisms of cellular function in hypoxic tissues
    • Shows clinical applications of HBO in difficult cases

    This book focuses on hyperbaric oxygenation (HBO) therapy from the molecular biology perspective and its clinical applications, including molecular mechanisms of HBO’s positive effect on cellular function in hypoxic tissues.

    HBO is a therapeutic tool that enhances oxygen supply to hypoxic tissues and improves wound healing/tissue remodeling. Currently HBO therapy is applied to a wide range of clinical cases, which include not only acute hypoxic diseases but also many chronic and refractory diseases involving tissue hypoxia or intractable infection. HBO therapy is a well-recognized regimen for many researchers and clinicians.

    The first half of the book outlines basic molecular mechanisms of HBO and their potential applications for clinical activities, while the second half describes the rationale behind introducing HBO therapy into suitable clinical cases and presents successful clinical reports. It is primarily written for HBO clinicians, physiologists and basic research scientists, but is also of interest to clinicians who have an interest in this field considering introducing HBO therapy.

    1. Front Matter

    Pages i-vii

    1. Stress Responses of the Cell Under Hyperbaric/Hyperoxic Environment
      1. Front Matter

    Pages 1-1

      1. Molecular Mechanisms of Hyperbaric Oxygen Therapy
        • Nariyoshi Shinomiya

    Pages 3-20

      1. Host Response Against Hyperbaric Diving Stresses
        • Nariyoshi Shinomiya

    Pages 21-41

      1. Hyperbaric Oxygen Preconditioning-Induced Neuroprotection
        • Kojiro Wada

    Pages 43-52

    1. Application of Hyperbaric Oxygen to the Treatment of Intractable Diseases
      1. Front Matter

    Pages 53-53

      1. Hyperbaric Oxygenation as an Adjunctive Therapy
        • Yasufumi Asai, Hiroshi Dohgomori

    Pages 55-65

      1. Treatment of Osteomyelitis by Hyperbaric Oxygen Therapy
        • Masayuki Kawashima, Takashi Yamaguchi, Hiroaki Tamura, Mahito Kawashima

    Pages 67-80

      1. Hyperbaric Oxygen Therapy in the Management of Severe Soft Tissue Injuries
        • Noriaki Yamada, Izumi Toyoda, Shinji Ogura

    Pages 81-103

      1. Evaluation of Hyperbaric Oxygen Therapy as a First-Line Treatment for Carbon Monoxide Poisoning
        • Kenji Taki, Shogo Goda

    Pages 105-130

      1. Recompression Therapy for Decompression Sickness and Arterial Gas Embolism
        • Fumitaka Ikomi

    Pages 131-152

  • Nariyoshi Shinomiya

    Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Japan

    Yasufumi Asai

    Hakodate Shintoshi Hospital, Hakodate, Japan

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