Anatomia, Bioquímica, Embriologia, Fisiologia, Histologia e Neuroanatomia Medicina Laboratorial e Patologia Clínica Animais Exóticos, Selvagens, Silvestres, Aves, Peixes, Mamíferos Marinhos, Zoologia
De: George Parker
ISBN: 9780323913935
2023, Academic Press
Capa dura
Páginas: 293
Histopathology Atlas of Acute Radiation Syndrome and Delayed Effects in Rhesus Macaques: Kidney, Lung, Heart, Intestine and Mesenteric Lymph Node provides a thoroughly illustrated review of the tissue damage and reparative changes associated with standardized irradiation doses in rhesus macaques. In addition to time-sequenced, routinely stained histologic sections, the book presents results of numerous histochemical, immunohistochemical and chromogenic in-situ stains that provide insights into the pathogenesis of radiation-associated tissue injury and repair. This book is compiled and written by a board-certified veterinary pathologist with more than 40 years of experience in the interpretation of experimentally induced tissue alterations in laboratory animals.
This is an important resource for researchers in the field of animal science radiation injury, including radiation oncologists and individuals involved in disaster preparedness related to accidental or deliberate radiation exposure in large populations.
Key features
Cover image
Title page
Table of Contents
Copyright
Foreword
Preface
Overview of studies
Irradiation protocol
Animal cage-side observations
Medical management
Dexamethasone treatment, nonsedated respiratory rate
Euthanasia
Necropsy and histology procedures
Acknowledgments
Funding
Further reading
Chapter 1. Radiation-associated changes in the kidney of rhesus macaques
Abstract
Overview
Staining and figures list
Detailed microscopic observations
References
Chapter 2. Radiation-associated changes in the lung of rhesus macaques
Abstract
Overview
Staining and figures list
Detailed microscopic observations
References
Chapter 3. Radiation-associated changes in the heart of rhesus macaques
Abstract
Overview
Stains and related figures
Detailed microscopic observations
References
Chapter 4. Radiation-associated changes in the jejunum of rhesus macaques
Abstract
Overview
Staining and figures list
Detailed microscopic observations
Chapter 5. Radiation-associated changes in the colon of rhesus macaques
Abstract
Overview
Staining and figure lists
Detailed colon observations
Chapter 6. Radiation-associated changes in the mesenteric lymph node of rhesus macaques
Abstract
Overview
Staining and figures list
Detailed microscopic observations
Index
Dr. George Parker
Currently serves as Senior Scientific Director, Global Pathology, at Charles River Laboratories. He received the Doctor of Veterinary Medicine (DVM) degree from the Auburn University College of Veterinary Medicine, completed a veterinary pathology residency at the Armed Forces Institute of Pathology, and received a PhD degree in immunology from Rutgers University. He is a diplomate of the American College of Veterinary Pathologists as well as the American Board of Toxicology, and a Fellow of the International Academy of Toxicologic Pathology. He has more than 30 years of experience as a toxicologic pathologist and has served as study pathologist on several hundred drug and chemical safety studies. He has published numerous book chapters and peer-reviewed journal articles that have been focused primarily on toxicologic pathology.
Affiliations and expertise
Senior Scientific Director, Global Pathology, Charles River Laboratories, Durham, NC, USA