• Comprehensive and up-to-date coverage of clostridial diseases

    The newly revised second edition of Clostridial Diseases of Animals is a timely update to the gold-standard resource for veterinary practitioners treating clostridial disease in animals. This is a comprehensive, detailed reference that emphasizes clinically relevant information on pathogenesis, pathology, microbiology, diagnostic techniques, clinical management, and treatment.

    The Second Edition takes a new One Health perspective, offering brand-new chapters that cover enteric, histotoxic, and neurotoxic clostridial diseases in animals and humans. The book also explores the reclassification of C. perfringens, providing references throughout to explain the level of evidence supporting each conclusion.

    Inside the book:

    • A thorough treatment of clostridial diseases with accurate coverage of new information and technologies
    • A reorganized gastrointestinal section reflecting the changes to the classification of C. perfringens
    • Practical discussions of enteric, histotoxic, and neurotoxic clostridial diseases
    • Fully cited references demonstrating the evidence base

    Written for veterinary clinicians, diagnosticians, pathologists, and microbiologists, Clostridial Diseases of Animals will also benefit regulators working in government agencies with a stake in this issue, as well as veterinary students.

  • Contributors

    Preface

    1 The Pathogenic clostridia

    1 Taxonomic relationships among the clostridia

    2 General physiologic and virulence properties of the pathogenic clostridia

    3 Brief description of animal pathogenic clostridia

    2 Toxins produced by the pathogenis clostridia

    4 Toxins of histotoxic clostridia: Clostridium chauvoei, Clostridium septicum, Clostridium novyi and Paeniclostridium sordellii

    5 Toxins of Clostridium perfringens

    6 Toxins of Clostridioides difficile

    7 Clostridium botulinum and Clostridium tetani neurotoxins

    3 Clostridial infections of the gastrointestinal system

    8 Diseases produced by Clostridium perfringens type A

    9 Diseases produced by Clostridium perfringens type B

    10 Diseases produced by Clostridium perfringens type C

    11 Diseases produced by Clostridium perfringens type D

    12 Diseases produced by Clostridium perfringens type E

    13 Diseases produced by Clostridium perfringens type F

    14 Diseases produced by Clostridium perfringens type G

    15 Diseases produced by Clostridioides difficile

    16 Disease caused by Clostridium colinum: Ulcerative enteritis of poultry and other avian species

    17 Diseases produced by Clostridium spiroforme

    18 Clostridial abomasitis of ruminants

    4 Clostridial histotoxic infections

    19 Blackleg

    20 Gas gangrene

    21 Gangrenous dermatitis of poultry

    22 Bacillary hemoglobinuria

    23 Infectious necrotic hepatitis

    24 Tyzzer disease

    5 Clostridial neurotoxic infections

    25 Tetanus

    26 Botulism

    27 Diseases caused by other clostridia producing neurotoxins

    6 Animal clostrifial diseases as zoonosis and animals as reservoir of human clostridial pathogens

    28 Animal clostrifial diseases as zoonosis and animals as reservoir of human clostridial pathogens

  • Francisco A. Uzal, DVM, FRVC, MSc, PhD, Dipl. ACVP

    Is a Distinguished Professor of Diagnostic Pathology and Branch Chief of the San Bernardino Laboratory of the California Animal Health and Food Safety at the University of California at Davis in Davis, California, USA.

    Bruce McClane, PhD, FAAM

    Is a Professor of Microbiology and Molecular Genetics at the University of Pittsburgh School of Medicine in Pittsburgh, Pennsylvania, United States.

    Iman Mehdizadeh Gohari, DVM, MSc, PhD

    Is a Research Assistant Professor at the Department of Microbiology and Molecular Genetics at the University of Pittsburgh School of Medicine in Pittsburgh, Pennsylvania, United States.

    Mauricio A. Navarro, DVM, MSc, PhD, Dipl. ACVP

    Is an Assistant Professor of Veterinary Anatomic Pathology at the Universidad Austral de Chile in Valdivia, Chile.

    Michel R. Popoff, DVM, PhD

    Is a former Associate Professor and Head of the Research Unit of Anaerobic Bacteria and Toxins and the National Reference Center for Anaerobic Bacteria and Botulism at the Institut Pasteur in Paris, France.

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