• The revised fifth edition of Clinical Laboratory Animal Medicine: An Introduction is an accessible guide to basic information for conducting animal research safely and responsibly. It includes a review of the unique anatomic and physiologic characteristics of laboratory animals, husbandry practices, and veterinary care of many animals frequently used in research, including rodents, rabbits, ferrets, zebrafish, nonhuman primates, and agricultural animals.

    The updated fifth edition adds two new chapters on zebrafish and large animals, new information on transgenic models and genetic editing, and expanded coverage of environmental enrichment and pain management. The book presents helpful tip boxes, images, and review questions to aid in comprehension and learning, and a companion website provides editable review questions and answers, instructional PowerPoints, and additional images not found in the book. This important text:

    • Provides a complete introduction to laboratory animal husbandry, diseases, and treatments
    • Offers a user-friendly format with helpful content that highlights important concepts
    • Contains new knowledge relating to technical methodologies, diseases, drug dosages, laws and regulations, and organizations
    • Covers information on regulations, facilities, equipment, housing, and research variables as well as veterinary care
    • Includes new chapters on zebrafish and cattle, sheep, goats, and pigs

    Written for veterinary technicians, veterinary students, practicing veterinarians, and research scientists, the fifth edition of Clinical Laboratory Animal Medicine continues to offer an essential guide to the ethical treatment and anatomic and physiological characteristics of research animals.

  • About the Authors xii

    Preface xiii

    About the Companion Website xiv

    1 Introduction to Laboratory Animal Medicine 1

    Animals Used in Research, Teaching, and Testing 2

    Ethical Considerations 8

    Organizations 12

    Bibliography 17

    Further Reading 18

    Chapter 1 Review 19

    2 Regulations, Policies, and Principles Governing the Care and Use of Laboratory Animals 22

    Animal Welfare Act and Regulations 22

    Public Health Service Policy on Humane Care and Use of Laboratory Animals 28

    Other Regulations, Policies, Guidance Documents, and Organizations 31

    References 36

    Further Reading 37

    Chapter 2 Review 37

    3 Facility Design, Housing, Equipment, and Management 39

    Laboratory Animal Facility Design 39

    Common Facility Classifications 46

    Housing 50

    Facility Equipment 59

    Management 66

    Bibliography 69

    Further Reading 69

    Chapter 3 Review 71

    4 Mice 74

    Genetics 74

    Microbiologic Classifications 76

    Uses 77

    Behavior 77

    Anatomic and Physiologic Features 78

    Breeding and Reproduction 80

    Husbandry 81

    Techniques 86

    Special Techniques: Transgenic Production Technology 96

    Therapeutic Agents 101

    Introduction to Diseases of Mice 101

    Viral Diseases 107

    References 114

    Further Reading 119

    Chapter 4 Review 122

    5 Rats 124

    Genetics 124

    Microbiologic Classifications 125

    Uses 126

    Behavior 126

    Anatomic and Physiologic Features 127

    Breeding and Reproduction 129

    Husbandry 130

    Techniques 133

    Therapeutic Agents 143

    Introduction to Diseases of Rats 144

    Bibliography 157

    Further Reading 162

    Chapter 5 Review 162

    6 Gerbils 165

    Uses 165

    Behavior 166

    Anatomic and Physiologic Features 166

    Breeding and Reproduction 167

    Husbandry 168

    Techniques 170

    Therapeutic Agents 176

    Introduction to Diseases of Gerbils 176

    Bibliography 181

    Further Reading 183

    Chapter 6 Review 184

    7 Hamsters 185

    Uses 185

    Behavior 186

    Anatomic and Physiologic Features 187

    Breeding and Reproduction 189

    Husbandry 190

    Techniques 192

    Therapeutic Agents 198

    Introduction to Diseases of Hamsters 198

    Bibliography 207

    Further Reading 209

    Chapter 7 Review 210

    8 Guinea Pigs 212

    Uses 212

    Behavior 213

    Anatomic and Physiologic Features 214

    Breeding and Reproduction 216

    Husbandry 218

    Techniques 219

    Therapeutic Agents 225

    Introduction to Diseases of Guinea Pigs 226

    Bibliography 238

    Further Reading 240

    Chapter 8 Review 242

    9 Chinchillas 243

    Uses 243

    Behavior 244

    Anatomic and Physiologic Features 244

    Breeding and Reproduction 246

    Husbandry 247

    Techniques 249

    Therapeutic Agents 253

    Introduction to Diseases of Chinchillas 255

    Bibliography 260

    Further Reading 262

    Chapter 9 Review 262

    10 Zebrafish 264

    Uses 264

    Behavior 265

    Anatomic and Physiologic Features 265

    Reproduction and Life Stages 266

    Husbandry 268

    Techniques 274

    Therapeutic Agents 278

    Introduction to Diseases of Zebrafish 278

    Bibliography 283

    Further Reading 284

    Chapter 10 Review 285

    11 Rabbits 286

    Breeds 286

    Uses 287

    Behavior 288

    Anatomic and Physiologic Features 288

    Breeding and Reproduction 291

    Husbandry 293

    Techniques 297

    Therapeutic Agents 308

    Introduction to Diseases of Rabbits 309

    Bibliography 326

    Further Reading 329

    Chapter 11 Review 331

    12 Ferrets 333

    Uses 333

    Behavior 334

    Anatomic and Physiologic Features 334

    Breeding and Reproduction 336

    Husbandry 337

    Techniques 339

    Therapeutic Agents 347

    Introduction to Diseases of Ferrets 347

    Bibliography 365

    Further Reading 369

    Chapter 12 Review 369

    13 Primates 371

    Taxonomy 371

    Uses 375

    Behavior 376

    Anatomic and Physiologic Features 377

    Breeding and Reproduction 378

    Husbandry 380

    Techniques 383

    Therapeutic Agents 390

    Introduction to Diseases of Nonhuman Primates 390

    Bibliography 410

    Further Reading 413

    Chapter 13 Review 416

    14 Cattle, Sheep, Goats, and Pigs 417

    Uses 417

    Behavior 418

    Anatomic and Physiologic Features 419

    Breeding and Reproduction 419

    Husbandry 420

    Techniques 424

    Therapeutic Agents 428

    Introduction to Diseases of Agricultural Animals of Particular Importance to Research 428

    Bibliography 434

    Further Reading 435

    Chapter 14 Review 435

    15 Research Variables, Biosecurity, and Colony Health Surveillance 437

    Research Variables 437

    Biosecurity and Exclusion of Contaminants 445

    Animal Colony Health Surveillance 448

    Bibliography 455

    Further Reading 455

    Chapter 15 Review 456

    Appendix 1: Normal Values 459

    Appendix 2: Comparative Biologic and Reproductive Values by Species 464

    Answers to Review Questions 467

    Index 474

  • Lesley A. Colby, DVM, MS, DACLAM

    Is an Associate Professor and Senior Director of Animal Resources and Operations in the Department of Comparative Medicine at the University of Washington in Seattle, Washington, USA.

    Megan H. Nowland, DVM, DACLAM

    Is an Associate Professor in the Unit for Laboratory Animal Medicine at the University of Michigan in Ann Arbor, Michigan, USA.

    Lucy H. Kennedy, DVM, DACLAM

    Is an Assistant Professor in the Unit for Laboratory Animal Medicine at the University of Michigan in Ann Arbor, Michigan, USA.

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