• With nearly 100 different autoimmune diseases reported to occur in domestic animal species, this evidence-based clinical reference is a must-have for every veterinary practice! Autoimmune Diseases in Domestic Animals, from noted veterinary author Ian R. Tizard, sheds light on both common and rare conditions, including skin diseases, diabetes mellitus, thyroiditis, and hemolytic anemia. Convenient and portable, this single-source review addresses autoimmune diseases in dogs, cats, horses, and livestock species with comprehensive coverage of treatment protocols, diagnostic procedures, and the latest pathogenesis studies.

    Key Features

    • All-in-one guide covers the basic science, clinical presentation, and treatment of this set of increasingly prevalent animal diseases.
    • Comprehensive information for each disease prepares students to communicate effectively with clients.
    • Reviews of the most recent relevant literature provide a clearer understanding of complex autoimmune diseases.
    • Detailed coverage facilitates the accurate diagnosis and rational treatment of immunologic diseases.
    • Information on autoimmune mouse strains and other animal models meets the needs of comparative immunology and research students.
    • Expert author Ian R. Tizard is a well-established veterinary writer who is world-renowned on the topic of immunology in veterinary medicine.
  • Chapter 1. Tolerance and the regulation of Immunity


    T Cell Tolerance

    Central T Cell Tolerance

    Negative Selection

    Receptor Editing

    Peripheral T Cell Tolerance

    Clonal Anergy

    B Cell Tolerance

    Peripheral B Cell Tolerance

    Duration of Tolerance

    Chapter 2. Mechanisms of Autoimmunity

    Induction of Autoimmunity

    Normal Immune Responses

    Antigens Hidden in Cells or Tissues (Cryptic Antigens)

    Antigens Generated by Molecular Changes

    Receptor Editing

    Abnormal Immune Responses

    Failure of Regulatory Control

    Infection-Induced Autoimmunity

    Molecular Mimicry

    Epitope Spreading

    Bystander Activation


    Predisposing Factors

    Genetic Predisposition

    Breed Predispositions

    Intestinal Microbiota

    Chapter 3. Pathogenesis of Autoimmune Diseases

    Mechanisms of Tissue Damage in Autoimmunity

    Type I Hypersensitivity

    Type II Hypersensitivity

    Type III Hypersensitivity

    Type IV Hypersensitivity

    Chapter 4. Autoimmune Endocrine Diseases

    Lymphocytic Thyroiditis


    Lymphocytic Parathyroiditis

    Autoimmune Diabetes Mellitus

    Atrophic Lymphocytic Pancreatitis

    Autoimmune Adrenalitis

    Chapter 5. Autoimmune Neurologic Diseases

    Equine Polyneuritis

    Canine Polyneuritis

    Steroid-Responsive Meningitis-Arteritis

    Necrotizing Meningoencephalitis

    Degenerative Myelopathy

    Cerebellar Degeneration

    Chapter 6. Autoimmune Eye Diseases

    Equine Recurrent Uveitis

    Uveodermatological Syndrome

    Immune-mediated Keratoconjunctivitis

    Keratoconjunctivitis Sicca

    Chronic Superficial Keratitis

    Chapter 7. Autoimmune Reproductive Diseases


    Contraceptive vaccines

    Chapter 8. Autoimmune Skin Diseases

    Hair Follicle Diseases

    Alopecia Areata

    Blistering Diseases

    Skin Basement Membrane Diseases

    Bullous Pemphigoid

    Linear Immunoglobulin A Dermatosis

    Epidermolysis Bullosa Acquisita

    Relapsing Polychondritis

    Chapter 9. Autoimmune Blood diseases

    Immune-Mediated Hemolytic Anemia

    Immune Suppression of Hematopoiesis

    Autoimmune Thrombocytopenia

    Chapter 10. Autoimmune Muscle diseases

    Myasthenia Gravis


    Autoimmune Masticatory Myositis

    Canine Cardiomyopathy


    Chapter 11. Autoimmune Liver and Kidney Diseases

    Chronic Active Hepatitis

    Autoimmune Nephritis

    Chapter 12. Systemic Lupus Erythematosis


    Genetic factors

    T cell abnormalities

    B cell abnormalities

    Impaired Apoptosis

    Multiple Autoantibodies

    Equine Lupus

    Canine Lupus

    Feline Lupus



    Discoid Lupus Erythematosus

    Sjögren’s Syndrome

    Chapter 13. Erosive Autoimmune Polyarthritis

    Rheumatoid Arthritis




    Chapter 14. Non-Erosive polyarthritis

    Equine Polyarthritis/Polysynovitis

    Canine Polyarthritis

    Lupus Polyarthritis

    Polyarthritis with Polymyositis

    Idiopathic Polyarthritis

    Feline Polyarthritis

    Cruciate Ligament Rupture

    Chapter 15. Immune-mediated vasculitides

    Immune Vasculitis

    Chapter 16. Diagnosis of Autoimmune Diseases

    Immunofluorescence assays

    Serologic assays


    Antiglobulin tests

    Rheumatoid factors

    Inflammation assays

    LE cell tests

    Acute Phase proteins

    Chapter 17. Treatment of Autoimmune Diseases

    Nonspecific Immunosuppression


    Cytotoxic Drugs

    Alkylating Agents

    Folic Acid Antagonists

    DNA Synthesis Inhibitors

    Selective Immunosuppression

    Calcineurin Inhibitors

    Target of Rapamycin Inhibitors

    Depletion of Lymphocytes

    Intravenous Immunoglobulin Therapy

    Cytokines and Monoclonal Antibodies

    Chapter 18. Autoimmunity in Laboratory Animals

    Autoimmune mouse strains

    NZB and NZW mice

    Other mouse strains

    Other autoimmune models

  • Ian R. Tizard

    University Distinguished Professor of Immunology,Department of Veterinary Pathobiology,The Texas Veterinary Medical Center,Texas A &M University College Station, Texas, USA