• Haschek and Rousseaux's Handbook of Toxicologic Pathology: Volume 1: Principles and Practice of Toxicologic Pathology is a key reference on the integration of structure and functional changes in tissues associated with the response to pharmaceuticals, chemicals and biologics. Volume 1 of the Fourth Edition covers the practice of toxicologic pathology in three parts: Principles of Toxicologic Pathology, Methods in Toxicologic Pathology, and the Practice of Toxicologic Pathology. Completely revised with a number of new chapters, Volume 1 of the Handbook of Toxicologic Pathology is an essential part of the most authoritative reference on toxicologic pathology for pathologists, toxicologists, research scientists, and regulators studying and making decisions on drugs, biologics, medical devices, and other chemicals, including agrochemicals and environmental contaminants.

    Key Features

    • Provides new chapters on digital pathology, juvenile pathology, in vitro/in vivo correlation, big data technologies and in-depth discussion of timely topics in the area of toxicologic pathology
    • Offers high-quality and trusted content in a multi-contributed work written by leading international authorities in all areas of toxicologic pathology
    • Features hundreds of full-color images in both the print and electronic versions of the book to highlight difficult concepts with clear illustrations

  • 1. Toxicology Pathology: An Introduction

    Part 1 Principles of Toxicologic Pathology

    2. Biochemical and Molecular Basis of Toxicity
    3. ADME Principles in Small Molecule Drug Discovery and Development: An Industrial Perspective
    4. Biotherapeutic ADME and PK/PD Principles
    5. Principles of Pharmacodynamics and Toxicodynamics
    6. Morphologic Manifestations of Toxic Cell Injury
    7. The Role of Pathology in Evaluation of Reproductive, Developmental, and Juvenile Toxicity
    8. Carcinogenesis: Mechanisms and Evaluation

    Part 2 Methods in Toxicologic Pathology

    9. Basic Approaches to Anatomic Toxicologic Pathology
    10. Clinical Pathology in Nonclinical Toxicity Testing
    11. Special Techniques in Toxicologic Pathology
    12. Digital Pathology and Tissue Image Analysis
    13. In Vivo Small Animal Imaging: A Comparison to Gross and Histopathologic Observations in Animal Models
    14. Biomarkers: Discovery, Qualification and Application
    15. Toxicogenomics: A Primer for Toxicologic Pathologists
    16. Experimental Design and Statistical Analysis for Toxicologic Pathologists

    Part 3 Animal and Alternative Models in Toxicologic Research

    17. Animal Models in Toxicologic Research: Rodents
    18. Animal Models in Toxicologic Research: Rabbit
    19. Animal Models in Toxicologic Research: Dog
    20. Animal Models in Toxicologic Research: Pig
    21. Animal Models in Toxicologic Research: Nonhuman Primate
    22. Animal Models in Toxicologic Research: Non-mammalian
    23. Genetically Engineered Animal Models in Toxicologic Research
    24. Alternative Models in Biomedical Research: In Silico, In Vitro, Ex Vivo, and Non-Traditional In Vivo Approaches

    Part 4 Practice of Toxicologic Pathology

    25. Nomenclature and Diagnostic Resources in Anatomic Toxicologic Pathology
    26. Pathology Peer Review
    27. Pathology and GLPs, Quality Control and Quality Assurance
    28. Practices to Optimize Generation, Interpretation, And Reporting of Pathology Data from Toxicity Studies
    29. Issues in Laboratory Animal Science that Impact Toxicologic Pathology

  • Wanda Haschek

    Wanda M Haschek-Hock, BVSc, PhD, DACVP, FIATP, ‎Professor Emerita, Dept of Veterinary Pathobiology, College of Veterinary Medicine University of Illinois at Urbana-Champaign, Urbana, Illinois, USA. Professor Haschek-Hock has served as president of the Society of Toxicologic Pathology and the Society of Toxicology’s Comparative and Veterinary Specialty Section, as well as Councilor of the American College of Veterinary Pathologists, board member of the American Board of Toxicology; as Associate Editor for Toxicological Sciences and for Toxicologic Pathology; as Editorial Board member for Fundamental and Applied Toxicology, Veterinary Pathology and Toxicologic Pathology. She has served as a member on the USFDA Veterinary Medicine Advisory Committee for the Center for Veterinary Medicine, the EPA’s FIFRA Science Advisory Panel, and National Academy of Sciences Committee. She currently serves on the Board of Directors of the C.L. Davis Foundation for the Advancement of Veterinary and Comparative Pathology. She was awarded the Society of Toxicologic Pathology’s Achievement Award in 2007 and the Midwest Regional Chapter – Society of Toxicology’s Kenneth DuBois Award in 2011.

    Affiliations and Expertise

    ‎Professor Emerita, Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA

    Colin Rousseaux

    Professor Rousseaux, BVSc [Hons], PhD, DABT, FRCPath, FIATP, FATS is a Fellow of the Royal College of Pathology, Diplomate of the American Board of Toxicology, Fellow of the Academy of Toxicological Sciences, and Fellow of the International Academy of Toxicologic Pathology. He is Professor (Adjunct) in the Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of Ottawa, Canada. He has 35 years of experience in comparative and toxicologic pathology with a research focus on herbal remedies, fetal development and teratology, and environmental pollutants. He has described, investigated, and evaluated numerous toxicologic pathology issues associated with pharmaceutical, pesticides, and agrochemicals. He has served on the editorial board of Toxicologic Pathology. He is a former president of the Society of Toxicologic Pathology.

    Affiliations and Expertise

    Adjunct Professor, Department of Pathology and Laboratory Medicine, University of Ottawa, Principal, Colin Rousseaux and Associates, Canada

    Matthew Wallig

    Professor Wallig, DVM, PhD, DACVP is a Diplomate of the American College of Veterinary Pathologists. He is Professor Emeritus in the Department of Pathobiology, College of Veterinary Medicine, the Department of Food Science and Human Nutrition, as well as the Division of Nutritional Sciences at the University of Illinois. His research has focused on the chemoprotective properties and mechanisms of phytochemicals in the diet, in particular those in cruciferous vegetables and soy, and the pathophysiology of pancreatic injury.

    Affiliations and Expertise

    Professor Emeritus, Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA

    Brad Bolon

    Brad Bolan, DVM, MS, PhD, SACVP, DABT, FATS, FIATP, President and Pathologist, GEMpath, Inc., Longmont, Colorado, USA During a 25-year career, Dr. Bolon has been employed in academia, contract research organizations, and two pharmaceutical firms before launching an experimental and toxicologic pathology practice. His main professional interests include comparative pathology of genetically engineered animals and toxicologic neuropathology. He is a past president of the Society of Toxicologic Pathology and is a recipient of the 2018 British Society of Toxicological Pathology’s Gopinath Lecture Award for excellence in toxicologic pathology.

    Affiliations and Expertise

    President and Pathologist, GEMpath, Inc., Longmont, Colorado, USA

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