Veterinary Clinics of North America
De: Lauren V. Schnabel
ISBN: 9780323938914
2023, Elsevier , Equine
Capa dura
Páginas: 240
In this issue of Veterinary Clinics of North America: Equine Practice, guest editor Ds. Lauren V. Schnabel brings her considerable expertise to the topic of Use of Biologic and Regenerative Therapies in Equine Practice. Top experts in the field explain what the main biologic and regenerative therapies are, what they contain, evidence to date for how they should be used, and how to monitor response to treatment. While the majority of the issue will focus on musculoskeletal applications, other indications for use will be discussed including wounds and ophthalmologic conditions as well as other inflammatory diseases.
Key Features
Contains 13 practice-oriented topics including equine bone marrow aspirate concentrate; equine stem cells: sources, practices, and potential safety concerns; advances in imaging techniques to guide therapies and monitor response to the treatment of musculoskeletal injuries; use of biologics and stem cells for wound healing in the horse; antimicrobial properties of equine stem cells and platelets; and more.
Provides in-depth clinical reviews on the use of biologic and regenerative therapies in equine practice, offering actionable insights for clinical practice.
Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
Cover image
Title page
Table of Contents
Copyright
Contributors
Forthcoming Issues
Preface
Dedications
Introduction to Equine Biologic and Regenerative Therapies
Key points
Introduction to equine biologic and regenerative therapies
Minimally processed blood-derived orthobiologics
Tissue-derived orthobiologics: minimally manipulated and culture expanded
Stem cell therapy: cellular concentrates
Stem cell therapy: culture expansion
Summary
Disclosure
Equine Platelet-Rich Plasma
Key points
Introduction
Rationale and definitions
Clinical use of platelet-rich plasma
Platelet activation
Concurrent nonsteroidal anti-inflammatory therapy
Complications
Future directions
Summary
Clinics care points
Disclosure
Equine Autologous Conditioned Serum and Autologous Protein Solution
Key points
Introduction
Autologous conditioned serum
Autologous protein solution
Summary
Disclosure
Equine Bone Marrow Aspirate Concentrate
Key points
Introduction
Generation of BMC
The cells in BMC
Biophysical and biochemical signals
Clinical applications of BMC
Summary
Clinics care points
Disclosure
Overview of Equine Stem Cells: Sources, Practices, and Potential Safety Concerns
Key points
Introduction
Equine stem cell sources
Equine stem cell practices
Potential safety concerns
Clinics care points
Disclosure
Funding
Use of Stem Cells for the Treatment of Musculoskeletal Injuries in Horses
Key points
Introduction
Discussion
Summary
Clinics care points
Disclosures
Advances in Imaging Techniques to Guide Therapies and Monitor Response to the Treatment of Musculoskeletal Injuries
Key points
Introduction
Diagnostic imaging modalities
Clinics care points
Conflict of interest
Disclosure
Advances in Regional Vascular Injection Techniques for the Delivery of Stem Cells to Musculoskeletal Injury Sites
Key points
Introduction
Comparison of different regional vascular injection techniques
Technical aspects of intra-arterial injections in standing horses
Clinical applications
Summary
Clinics care points
Interactions Between Biologic Therapies and Other Treatment Modalities
Key points
Introduction
Discussion
Summary
Disclosure
Clinics care points
Use of Biologics and Stem Cells for Wound Healing in the Horse
Key points
Background
Evidence for the efficacy of biologic therapies for equine skin wounds
Future directions
Summary
Clinics care points
Disclosure
Use of Biologics and Stem Cells in Equine Ophthalmology
Key points
Introduction
Corneal ulceration
Immune-mediated keratitis
Uveitis and ocular posterior segment disease
Retinal detachment
Summary
Clinics care points
Disclosure
Use of Biologics and Stem Cells in the Treatment of Other Inflammatory Diseases in the Horse
Key points
Mesenchymal stem cells modulate the immune system
How mesenchymal stem cells modulate the immune system
Endotoxemia in the horse
Recurrent airway obstruction in the horse
Gastrointestinal system and mesenchymal stem cells
Mesenchymal stem cell treatment of laminitis in the horse
Summary
Clinics care points
Disclosure
Antimicrobial Properties of Equine Stromal Cells and Platelets and Future Directions
Key points
Summary
Evidence for antimicrobial properties of equine mesenchymal stromal cells
Methods to enhance antimicrobial properties of mesenchymal stromal cells
Future directions with microcapsules and exosome-based therapies
Potential applications and challenges with mesenchymal stromal cells in equine practice
Evidence for antimicrobial properties of equine platelet products
Methods to enhance antimicrobial properties of equine platelet products
Potential applications and challenges with platelet lysate products in equine practice
Summary
Clinics care points
Conflicts of interest
Lauren V. Schnabel
Affiliations and expertise
Diplomate ACVS (LA), Diplomate ACVSMR (Equine), North Carolina State University College of Veterinary Medicine , Department of Clinical Sciences