Doenças autoimunes, Imunologia
Autoimmune Diseases In Domestic Animals, 1st Edition
De: Ian R. Tizard
ISBN: 9780323848138
2022
Capa mole
Páginas: 300
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With nearly 100 different autoimmune diseases reported to occur in domestic animal species, this evidence-based clinical reference is a must-have for every veterinary practice! Autoimmune Diseases in Domestic Animals, from noted veterinary author Ian R. Tizard, sheds light on both common and rare conditions, including skin diseases, diabetes mellitus, thyroiditis, and hemolytic anemia. Convenient and portable, this single-source review addresses autoimmune diseases in dogs, cats, horses, and livestock species with comprehensive coverage of treatment protocols, diagnostic procedures, and the latest pathogenesis studies.
Key Features- All-in-one guide covers the basic science, clinical presentation, and treatment of this set of increasingly prevalent animal diseases.
- Comprehensive information for each disease prepares students to communicate effectively with clients.
- Reviews of the most recent relevant literature provide a clearer understanding of complex autoimmune diseases.
- Detailed coverage facilitates the accurate diagnosis and rational treatment of immunologic diseases.
- Information on autoimmune mouse strains and other animal models meets the needs of comparative immunology and research students.
- Expert author Ian R. Tizard is a well-established veterinary writer who is world-renowned on the topic of immunology in veterinary medicine.
Chapter 1. Tolerance and the regulation of Immunity
Tolerance
T Cell Tolerance
Central T Cell Tolerance
Negative Selection
Receptor Editing
Peripheral T Cell Tolerance
Clonal Anergy
B Cell Tolerance
Peripheral B Cell Tolerance
Duration of Tolerance
Chapter 2. Mechanisms of Autoimmunity
Induction of Autoimmunity
Normal Immune Responses
Antigens Hidden in Cells or Tissues (Cryptic Antigens)
Antigens Generated by Molecular Changes
Receptor Editing
Abnormal Immune Responses
Failure of Regulatory Control
Infection-Induced Autoimmunity
Molecular Mimicry
Epitope Spreading
Bystander Activation
Microchimerism
Predisposing Factors
Genetic Predisposition
Breed Predispositions
Intestinal Microbiota
Chapter 3. Pathogenesis of Autoimmune Diseases
Mechanisms of Tissue Damage in Autoimmunity
Type I Hypersensitivity
Type II Hypersensitivity
Type III Hypersensitivity
Type IV Hypersensitivity
Chapter 4. Autoimmune Endocrine Diseases
Lymphocytic Thyroiditis
Hyperthyroidism
Lymphocytic Parathyroiditis
Autoimmune Diabetes Mellitus
Atrophic Lymphocytic Pancreatitis
Autoimmune Adrenalitis
Chapter 5. Autoimmune Neurologic Diseases
Equine Polyneuritis
Canine Polyneuritis
Steroid-Responsive Meningitis-Arteritis
Necrotizing Meningoencephalitis
Degenerative Myelopathy
Cerebellar Degeneration
Chapter 6. Autoimmune Eye Diseases
Equine Recurrent Uveitis
Uveodermatological Syndrome
Immune-mediated Keratoconjunctivitis
Keratoconjunctivitis Sicca
Chronic Superficial Keratitis
Chapter 7. Autoimmune Reproductive Diseases
Infertility
Contraceptive vaccines
Chapter 8. Autoimmune Skin Diseases
Hair Follicle Diseases
Alopecia Areata
Blistering Diseases
Skin Basement Membrane Diseases
Bullous Pemphigoid
Linear Immunoglobulin A Dermatosis
Epidermolysis Bullosa Acquisita
Relapsing Polychondritis
Chapter 9. Autoimmune Blood diseases
Immune-Mediated Hemolytic Anemia
Immune Suppression of Hematopoiesis
Autoimmune Thrombocytopenia
Chapter 10. Autoimmune Muscle diseases
Myasthenia Gravis
Polymyositis
Autoimmune Masticatory Myositis
Canine Cardiomyopathy
Dermatomyositis
Chapter 11. Autoimmune Liver and Kidney Diseases
Chronic Active Hepatitis
Autoimmune Nephritis
Chapter 12. Systemic Lupus Erythematosis
Pathogenesis
Genetic factors
T cell abnormalities
B cell abnormalities
Impaired Apoptosis
Multiple Autoantibodies
Equine Lupus
Canine Lupus
Feline Lupus
Diagnosis
Treatment
Discoid Lupus Erythematosus
Sjögren’s Syndrome
Chapter 13. Erosive Autoimmune Polyarthritis
Rheumatoid Arthritis
Pathogenesis
Diagnosis
Treatment
Chapter 14. Non-Erosive polyarthritis
Equine Polyarthritis/Polysynovitis
Canine Polyarthritis
Lupus Polyarthritis
Polyarthritis with Polymyositis
Idiopathic Polyarthritis
Feline Polyarthritis
Cruciate Ligament Rupture
Chapter 15. Immune-mediated vasculitides
Immune Vasculitis
Chapter 16. Diagnosis of Autoimmune Diseases
Immunofluorescence assays
Serologic assays
Hemagglutinins
Antiglobulin tests
Rheumatoid factors
Inflammation assays
LE cell tests
Acute Phase proteins
Chapter 17. Treatment of Autoimmune Diseases
Nonspecific Immunosuppression
Glucocorticosteroids
Cytotoxic Drugs
Alkylating Agents
Folic Acid Antagonists
DNA Synthesis Inhibitors
Selective Immunosuppression
Calcineurin Inhibitors
Target of Rapamycin Inhibitors
Depletion of Lymphocytes
Intravenous Immunoglobulin Therapy
Cytokines and Monoclonal Antibodies
Chapter 18. Autoimmunity in Laboratory Animals
Autoimmune mouse strains
NZB and NZW mice
Other mouse strains
Other autoimmune models
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Ian R. Tizard
University Distinguished Professor of Immunology,Department of Veterinary Pathobiology,The Texas Veterinary Medical Center,Texas A &M University College Station, Texas, USA