• Advances in the Canine Cranial Cruciate Ligament, Second Edition presents in-depth, focused, and updated coverage of current knowledge on cruciate ligament rupture, using a multidisciplinary, evidence-based approach.

    • Presents a state-of-the-art summary of the most recent knowledge on this important cause of lameness in dogs
    • Led by a highly respected surgeon and researcher, with chapters written by leading experts in the field
    • Provides an update to the groundbreaking first edition, with six new chapters
  • About the Editor xi

    Foreword to the Second Edition xiii
    Kenneth A. Johnson

    Foreword xv
    R. Randy Basinger, ACVS Foundation

    Preface xvii
    Peter Muir

    Acknowledgements xix
    Peter Muir

    Contributing Authors xxi

    I Structure and Function 1

    Introduction 1
    Peter Muir

    1 Morphology and Function of the Cruciate Ligaments 3
    Hilde de Rooster and Eithne Comerford

    2 Biomechanics of the Cruciate Ligaments 13
    Susannah J. Sample

    3 Cruciate Ligament Remodeling and Repair 21
    Connie S. Chamberlain, Erin E. Crowley, and Ray Vanderby Jr.

    4 Meniscal Structure and Function 31
    Antonio Pozzi and James L. Cook

    5 Biomechanics of the Normal and Cranial Cruciate Ligament-Deficient Stifle 39
    Antonio Pozzi and Stanley E. Kim

    II Etiopathogenesis of Cruciate Ligament Rupture 45

    Introduction 45
    Peter Muir

    6 Histology of Cruciate Ligament Rupture 47
    Kei Hayashi

    7 Genetics of Cruciate Ligament Rupture 57
    Lauren A. Baker and Peter Muir

    8 Cruciate Ligament Matrix Metabolism and Development of Laxity 65
    Eithne Comerford

    9 Morphological Risk Factors for Cruciate Ligament Rupture 73
    Eithne Comerford

    10 Role of Nitric Oxide Production and Matrix Protease Activity in Cruciate Ligament Degeneration 81
    David E. Spreng and Simone Forterre

    11 Role of Antibodies to Collagen Type I and II 89
    Hilde de Rooster and Eithne Comerford

    12 Synovitis Precedes Stifle Instability Associated with Cruciate Ligament Rupture 93
    Jason A. Bleedorn

    13 Role of Synovial Immune Responses in Stifle Synovitis 101
    Peter Muir

    III Clinical Features 107

    Introduction 107
    Peter Muir

    14 Epidemiology of Cruciate Ligament Rupture 109
    Lauren A. Baker and Peter Muir

    15 History and Clinical Signs of Cruciate Ligament Rupture 115
    Peter Muir

    16 Partial Rupture of the Cranial Cruciate Ligament 119
    Peter Muir

    17 Caudal Cruciate Ligament Rupture 123
    Peter Muir

    18 Stress Imaging of the Stifle 127
    Stanley E. Kim

    19 Stifle Ultrasonography 135
    Cristi R. Cook

    20 Computed Tomography (CT) of the Stifle 141
    Ingrid Gielen and Henri van Bree

    21 Magnetic Resonance Imaging of the Stifle 155
    Peter V. Scrivani

    22 Risk Prediction of Cruciate Ligament Rupture using Stifle Diagnostic Imaging 165
    Peter Muir

    IV Surgical Treatment 169

    Introduction 169
    Peter Muir

    23 Arthroscopy and Arthrotomy of the Stifle 171
    Brian S. Beale, Donald A. Hulse, Antonio Pozzi, and Peter Muir

    24 Joint Lavage 185
    Peter Muir

    25 Extracapsular Stabilization 189
    Selena Tinga and Stanley E. Kim

    26 Intra-Articular Repair for Cranial Cruciate Ligament Rupture in the Dog 201
    Jeffery J. Biskup and Michael G. Conzemius

    27 Tibial Plateau Leveling Osteotomy 217
    Susan L. Schaefer

    28 Tibial Tuberosity Advancement 227
    Randy J. Boudrieau

    29 Closing Cranial Wedge Ostectomy and Triple Tibial Osteotomy 243
    Simon C. Roe

    30 Treatment of Excessive Tibial Plateau Angle 253
    Michael P. Kowaleski

    31 Surgical Management of Cruciate Ligament Rupture Combined with Patella Luxation 261
    Anke Langenbach and Denis J. Marcellin-Little

    32 Biomechanics of the Cranial Cruciate Ligament-Deficient Stifle Treated by Tibial Osteotomies 271
    Antonio Pozzi, Stanley E. Kim, and Selena Tinga

    33 Arthroscopic Follow-Up after Surgical Stabilization of the Stifle 279
    Brian S. Beale and Donald A. Hulse

    34 Cranial Cruciate Ligament Debridement 291
    David E. Spreng

    35 Surgical Treatment of Concurrent Meniscal Injury 295
    Samuel P. Franklin, James L. Cook, and Antonio Pozzi

    36 Meniscal Release 301
    Antonio Pozzi and James L. Cook

    37 Progression of Osteoarthritis after Stifle Stabilization Surgery 307
    Susannah J. Sample

    38 Clinical Outcomes after Surgical Treatment of Cruciate Ligament Rupture 313
    Mary Sarah Bergh and Steven C. Budsberg

    39 Success and Failure after Stifle Stabilization Surgery 317
    Michael G. Conzemius and Richard B. Evans

    40 Diagnosis and Management of Orthopaedic Infection after Stifle Surgery 323
    Noel M.M. Moens

    V Medical Management of Cruciate Ligament Rupture 331

    Introduction 331
    Peter Muir

    41 Medical Therapy for Stifle Osteoarthritis 333
    Steven C. Budsberg

    42 Rehabilitation for Dogs with Cruciate Ligament Rupture 343
    Denis J. Marcellin-Little and Courtney J. Arnoldy

    VI Future Directions 353

    Introduction 353
    Peter Muir

    43 Clinical Research Design and Patient-Oriented Outcomes 355
    Dorothy Cimino Brown

    44 Total Knee Replacement in the Dog 363
    Matthew J. Allen, William D. Liska, and Valentina Brioschi

    45 Regenerative Medicine and Cranial Cruciate Ligament Repair 371
    Gabriel S. Perrone, Martha M. Murray, and Patrick Vavken

    46 Disease-Modifying Medical and Cell-Based Therapy 379
    Susannah J. Sample and Peter Muir

    Index 385

  • Peter Muir, BVSc, MVetClinStud, PhD, Diplomate ACVS, ECVS, is the Melita Grunow Family Professor of Companion Animal Health at the University of Wisconsin-Madison School of Veterinary Medicine in Madison, Wisconsin, USA.